The Medline Programme is the medical line of predictive DNA tests aimed at the identification of the predisposition to common diseases among the World population, especially as far as the female gender is concerned. The Medline Programme DNA tests are an extension to the iGenesis Programme and need to be integrated in the broader context of health management and prevention.
The genetic tests belonging to this line represent the tool by which qualified specialists can introduce their patients to a personalized disease prevention plan.
Genetic predisposition to Osteoporosis and to articular cartilage damage
The Osteo DNA test deals with bone health and investigates individual predisposition to osteoporosis and articular cartilage damage.
The innovative genetic panel studied by DF Medica takes into consideration not only the Metabolism of Vitamin D and Calcium, but also hormonal factors: the Single Nucleotide Polymorphisms selected are all part of the same pathway involved in the regulation of the accumulation and in the turnover of bone mass.
Osteoporosis is a highly hereditable disease characterized both by genetic risk factors and by the interaction between genetic factors and environmental factors, such as nutrition and physical activity. All these factors must be considered as a whole to the purpose of prevention.
At the same time, it is essential to prevent articular cartilage damage, which occurs with a progressive wear of articulations as a consequence of limited elasticity of the cartilage. The genetic predisposition is an important indicator for athletes and for whoever practices activities which represent a significant stress on articulations.
The Medline Osteo genetic panel has been elaborated on the basis of studies on thousands of individuals and has been confirmed by relevant meta-analyses. The SNPs included in the panel have been proven to be founded by a large number of studies with wide sample-sizes.
MEDLINE H. THROMBOPHILIA
Genetic predisposition to Hereditary Thrombophilia
The H. Thrombophilia DNA test allows to identify individual predisposition to Hereditary Thrombophilia, a condition of increased thrombotic risk. The prevention plan related to this disease will take into consideration aspects and habits belonging to the everyday life of Women of every age, which, together with a genetic predisposition, could represent significant risk factors.
Hereditary Thrombophilia (genetic predisposition to thrombosis) is a condition of increased thrombotic risk at vein or at artery level: the blood coagulates inside a blood vessel, it clings to the wall of the vessel, thus leading to a partial or total obstruction and altering or blocking the blood flow. Hereditary Thrombophilia makes its first appearance at a relatively early age (under 45 years) with recurrent thrombotic episodes. In about 50% of cases of Hereditary Thrombophilia it is possible to identify associated risk factors, such as surgery, pregnancy, intake of oral contraceptives and prolonged immobilization. Also certain environmental factors, when associated to genetic and risk factors, could predispose to this disease, such as cigarette smoke, obesity, diabetes, hypertension and hypercholesterolemia. The H.Thrombophilia genetic test analyses the genes implied in blood clotting and allows for the identification of the predisposition to this disease.